Outbound lanes on the Eastern Fwy and EastLink are now open.
EastLink remains closed inbound between Canterbury Rd and Springvale Rd.
Shots have been fired after the driver hit a police officer and sped away from a road block on EastLink.
The officer was knocked down by the car near the entrance of the Melba Tunnel.
"The driver did not pull over as directed by police which caused an officer to jump out of the way. He received minor injuries and was taken to hospital," Police say in a statement.
Eastlink is closed in both directions from Springvale Road to Whitehorse Road.
Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or they can file a confidential report a www.crimestoppersvic.com.au